Deregulation of cdk5 in Hippocampal Sclerosis
نویسندگان
چکیده
منابع مشابه
Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity
Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in various neurodegenerative conditions. However, their underlying mechanisms are poorly understood. Here, we show that deregulation of histone deacetylase 1 (HDAC1) activity by p25/Cdk5 induces aberrant cell-cycle activity and double-strand DNA breaks leading to neurotoxicity. In a transgenic model fo...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 2006
ISSN: 0022-3069
DOI: 10.1097/01.jnen.0000195940.48033.a2